The role of prechordal mesendoderm in neural patterning

Curr Opin Neurobiol. 2001 Feb;11(1):27-33. doi: 10.1016/s0959-4388(00)00170-7.


Prechordal mesendoderm is formed in response to Nodal and maternal beta-Catenin signaling and is regulated by signals from anterior endoderm and chordamesoderm. Prechordal mesendodermal cells are involved in neural induction and in anteroposterior and dorsoventral neural patterning. Inhibitors of Wnt and BMP growth factors secreted by prechordal mesendoderm mediate neural induction and anteroposterior and dorsoventral patterning, whereas SHH and TGF betas mediate dorsoventral patterning.

Publication types

  • Review

MeSH terms

  • Animals
  • Chordata, Nonvertebrate / embryology*
  • Endoderm / physiology*
  • Humans
  • Nervous System / embryology*