Specification of neuronal fates in the ventral neural tube

Curr Opin Neurobiol. 2001 Feb;11(1):43-9. doi: 10.1016/s0959-4388(00)00172-0.


The generation of distinct classes of neurons at defined positions is a fundamental step in the development of the vertebrate central nervous system. Recent work has begun to reveal the extracellular signals and transcriptional mediators that direct the pattern of generation of distinct neuronal subtypes in the neural tube. This work has provided a framework to understand the patterning of the ventral neural tube and is permitting molecular analyses of the assembly of functional neuronal circuits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Central Nervous System / chemistry*
  • Central Nervous System / embryology*
  • Hedgehog Proteins
  • Homeodomain Proteins / metabolism
  • Humans
  • Neurons / physiology
  • Proteins / metabolism
  • Signal Transduction / physiology
  • Stem Cells / physiology
  • Trans-Activators*


  • Hedgehog Proteins
  • Homeodomain Proteins
  • Proteins
  • Trans-Activators