The LDL receptor gene family: signaling functions during development

Curr Opin Neurobiol. 2001 Feb;11(1):74-81. doi: 10.1016/s0959-4388(00)00176-8.


The traditional views regarding the biological functions of the low-density lipoprotein (LDL) receptor gene family have been revisited recently with new evidence that at least some of the members of this receptor family act as signal-transduction molecules. Known for their role in endocytosis, particularly of their namesake the LDLs, and for their role in the prevention of atherosclerosis, these receptors belong to an ancient family with numerous ligands, effector molecules and functions. Recent evidence implicates this family of receptors in diverse signaling pathways, long-term potentiation and neuronal degeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Endocytosis / genetics
  • Humans
  • Protein Sorting Signals / genetics*
  • Protein Sorting Signals / physiology
  • Receptors, LDL / genetics*
  • Signal Transduction / genetics*


  • Protein Sorting Signals
  • Receptors, LDL