The role of Notch and Rho GTPase signaling in the control of dendritic development

Curr Opin Neurobiol. 2001 Feb;11(1):111-7. doi: 10.1016/s0959-4388(00)00181-1.

Abstract

Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest that the differential activation of Notch receptors and Rho-family GTPases by extracellular signals may be important in the generation of morphological diversity in the developing nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Dendrites / physiology*
  • Humans
  • Membrane Proteins / physiology*
  • Receptors, Cell Surface / physiology*
  • Receptors, Notch
  • Signal Transduction / physiology*

Substances

  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Notch