Dendritic arbor development and synaptogenesis

Curr Opin Neurobiol. 2001 Feb;11(1):118-26. doi: 10.1016/s0959-4388(00)00182-3.


In vivo studies indicate that synaptic activity promotes dendritic arbor elaboration at early stages of brain development. At later stages of development, synaptic activity stabilizes dendritic structure. The different roles of synaptic activity with respect to structural plasticity probably reflect the regulated spatiotemporal expression of key components within signaling pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / growth & development
  • Brain Chemistry / physiology
  • Dendrites / physiology*
  • GTP Phosphohydrolases / physiology
  • Humans
  • Nervous System / chemistry
  • Nervous System / growth & development*
  • Synapses / physiology*


  • GTP Phosphohydrolases