Expression patterns of musashi homologs of the ascidians, Halocynthia roretzi and Ciona intestinalis

Dev Genes Evol. 2000 Mar;210(3):162-5. doi: 10.1007/s004270050024.


The gene family encoding RNA-binding proteins includes important regulators involved in the neurogenesis in both protostomes and deuterostomes. We isolated cDNAs of the ascidian homolog of one of the RNA-binding proteins, MUSASHI, from Halocynthia roretzi and Ciona intestinalis. The predicted amino acid sequences contained two RNA-recognition and RNA-binding motifs in the N-terminus and an ascidian-specific YG-rich domain in the C-terminus. Maternal transcripts of musashi were ubiquitous in early cleavage-stage embryos. Ascidian musashi had three domains of zygotic expression: the brain, nerve cord, and mesenchyma. The temporal order of the onset in these domains was highly divergent between the two species of ascidian examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA, Complementary
  • Drosophila Proteins*
  • In Situ Hybridization
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • RNA-Binding Proteins / genetics*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Urochordata / genetics*


  • DNA, Complementary
  • Drosophila Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • msi protein, Drosophila

Associated data

  • GENBANK/AB030275