Effects of diuril and dilantin on blood glucose and insulin levels in late pregnancy

Obstet Gynecol. 1975 Feb;45(2):159-62.


In order to evaluate the carbohydrate metabolic effects of certain drug therapies used in treating the toxemia syndrome, 75 term pregnant women were studied with two intravenous glucose tolerance tests performed 1 week apart. During the 2-hour tests, both blood glucose and plasma insulin were measured. The women were randomly assigned to three treatment groups, and during the week between tests they received:a) no drugs (control or C group);b) Diuril, 500 mg/day (Dgroup); or c)Dilantin, 100 mg, t.i.d. (DL group). Each group was of similar age, weight, and gestational age. There were no significant changes in any of the glucose curves. Both drug-treated groups demonstrated insulin changes. In contrast to the C group, the D group showed an elevation of the plasma insulin values during the second test, and the DL group had a lowering of plasma insulin levels in the second test. Thus, both drugs had minor effects on carbohydrate metabolism during short-term use. However, a more marked metabolic effect of these drugs must be considered when using them at higher dosages or for a longer duration.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Glucose / analysis*
  • Chlorothiazide / pharmacology*
  • Chlorothiazide / therapeutic use
  • Dietary Carbohydrates / metabolism*
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood*
  • Phenytoin / pharmacology*
  • Phenytoin / therapeutic use
  • Pre-Eclampsia / drug therapy*
  • Pre-Eclampsia / metabolism
  • Pregnancy
  • Pregnancy Trimester, Third
  • Pregnancy in Diabetics / metabolism


  • Blood Glucose
  • Dietary Carbohydrates
  • Insulin
  • Phenytoin
  • Chlorothiazide