No beneficial effect of interferon-gamma treatment in 2 human immunodeficiency virus-infected patients with Mycobacterium avium complex infection

F N Lauw; J T van Der Meer; J de Metz; S A Danner; T van Der Poll

doi:10.1086/318705

No beneficial effect of interferon-gamma treatment in 2 human immunodeficiency virus-infected patients with Mycobacterium avium complex infection

Clin Infect Dis. 2001 Feb 15;32(4):e81-2. doi: 10.1086/318705. Epub 2001 Feb 7.

Authors

F N Lauw¹, J T van Der Meer, J de Metz, S A Danner, T van Der Poll

Affiliation

¹ Department of Infectious Diseases, Tropical Medicine, and AIDS, Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.

PMID: 11181141
DOI: 10.1086/318705

Abstract

Two human immunodeficiency virus-infected patients with refractory disseminated Mycobacterium avium complex infection were treated with recombinant interferon-gamma (IFN-gamma) given subcutaneously for 3 and 4 months, respectively. Although both patients demonstrated some clinical improvement initially, IFN-gamma therapy did not produce sustained benefit.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / drug therapy*
AIDS-Related Opportunistic Infections / microbiology
Adult
Female
Humans
Interferon-gamma / therapeutic use*
Male
Mycobacterium avium Complex*
Mycobacterium avium-intracellulare Infection / drug therapy*
Mycobacterium avium-intracellulare Infection / microbiology
Treatment Outcome

Substances

Interferon-gamma