Abstract
Microcin H47, a gene-encoded peptide antibiotic produced by a natural Escherichia coli strain, was shown to be secreted by a three-component ATP-binding cassette exporter which was revealed to be strongly related to that of colicin V. The results of sequence and gene fusion analyses, as well as heterologous complementation assays, are presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / genetics*
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ATP-Binding Cassette Transporters / physiology
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Amino Acid Sequence
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Anti-Bacterial Agents
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Bacterial Proteins / genetics*
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Bacterial Proteins / physiology
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Colicins / chemistry
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DNA, Bacterial / analysis
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Escherichia coli / genetics*
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Escherichia coli / physiology
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Escherichia coli Proteins*
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Molecular Sequence Data
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Multigene Family
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Peptides
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Restriction Mapping
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Sequence Homology, Amino Acid
Substances
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ATP-Binding Cassette Transporters
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Anti-Bacterial Agents
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Bacterial Proteins
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Colicins
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DNA, Bacterial
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Escherichia coli Proteins
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MchE protein, E coli
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MchF protein, E coli
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Peptides