The implications for cardiac recovery of left ventricular assist device support on myocardial collagen content

Am J Surg. 2000 Dec;180(6):498-501; discussion 501-2. doi: 10.1016/s0002-9610(00)00553-5.


Background: To define the beneficial cellular changes that occur with chronic ventricular unloading, we determined the effect of left ventricular assist device (LVAD) placement on myocardial fibrosis.

Methods: We obtained paired myocardial samples (before and after LVAD implantation) from 10 patients (aged 43 to 64 years) with end-stage cardiomyopathy. We first determined regional collagen expression of an explanted heart by a computerized semiquantitative analysis of positive picro-sirius red stained areas.

Results: We found that there was no statistically significant difference in collagen content between regions of the failed heart studied. Next we determined collagen content in these paired myocardial biopsies pre- and post-LVAD implantation. All 10 patients had significant reductions in collagen content after LVAD placement with a mean reduction of 82% (percent of tissue area stained decreased from 32% +/- 4% to 4% +/- 0.8%, P < 0.001).

Conclusion: In summary, these data demonstrate that chronic mechanical circulatory support significantly reduces fibrosis in the failing myocardium.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Cardiomyopathy, Dilated / surgery
  • Collagen / analysis*
  • Female
  • Heart-Assist Devices*
  • Humans
  • Male
  • Middle Aged
  • Myocardial Ischemia / surgery
  • Myocardium / chemistry*
  • Myocardium / pathology


  • Collagen