Delayed behavioral effects of beta-casomorphin-7 depend on age and gender of albino rat pups

V A Dubynin; I V Malinovskaya; Y A Ivleva; L A Andreeva; A A Kamenskii; I P Ashmarin

Delayed behavioral effects of beta-casomorphin-7 depend on age and gender of albino rat pups

Bull Exp Biol Med. 2000 Nov;130(11):1031-4.

Authors

V A Dubynin¹, I V Malinovskaya, Y A Ivleva, L A Andreeva, A A Kamenskii, I P Ashmarin

Affiliation

¹ Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. dubynin@5.human.bio.msu.ru

PMID: 11182807

Abstract

Systemic administration of beta-casein heptapeptide beta-casomorphin-7 (YPFPGPI, 1 mg/kg daily) to 10-23-day-old albino rat pups produced delayed anxiolytic effects, which were more pronounced in female than in male rats. Experimental findings confirm our assumption on the important role of nutritional opioids in brain development in newborn mammals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acoustic Stimulation
Age Factors
Animals
Anti-Anxiety Agents / metabolism
Anti-Anxiety Agents / pharmacology*
Endorphins / metabolism
Endorphins / pharmacology*
Escape Reaction / drug effects*
Female
Male
Motor Activity / drug effects
Narcotics / metabolism*
Peptide Fragments / metabolism
Peptide Fragments / pharmacology*
Rats
Stress, Physiological

Substances

Anti-Anxiety Agents
Endorphins
Narcotics
Peptide Fragments
beta-casomorphin 7