Effects of aniracetam on impaired sleep patterns in stroke-prone spontaneously hypertensive rats

Psychiatry Clin Neurosci. 2000 Jun;54(3):314-6. doi: 10.1046/j.1440-1819.2000.00693.x.


The aim of the present study was to determine the pattern of sleep disturbances and the effects on sleep of aniracetam, a cognitive enhancer, in stroke-prone spontaneously hypertensive rats (SHRSP). Compared with normotensive control rats, SHRSP exhibited an impaired sleep pattern characterized by suppressed diurnal rapid eye movement (REM) sleep and excessive nocturnal non-REM sleep. At a dose of 30 mg/kg per day p.o., aniracetam increased REM sleep in the light period after administration for 5 consecutive days. Consequently, suppressed REM sleep in SHRSP was restored by repeated treatment with aniracetam. Aniracetam could be useful in improving REM sleep impairment associated with vascular dementia.

MeSH terms

  • Animals
  • Male
  • Nootropic Agents / pharmacology*
  • Polysomnography
  • Pyrrolidinones / pharmacology*
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Sleep Stages / drug effects*
  • Sleep, REM / drug effects


  • Nootropic Agents
  • Pyrrolidinones
  • aniracetam