[Fetal exposure to endocrine disruptors]

Nihon Rinsho. 2000 Dec;58(12):2508-13.
[Article in Japanese]


Endocrine disruptors act to alter blood hormone levels or the subsequent action of hormones. Disturbances of hormonal regulation during fetal or postnatal development in human may induce adverse effects, but these adverse effects of endocrine disruptors on humans are subtle. We investigated fetal exposure to endocrine disruptors in Japan by analyzing umbilical cords or cord sera. Many endocrine disruptors including dioxins, polychlorinated biphenyls, organochlorine pesticides, bisphenol A, nonylphenol and phytoestrogen were detected in umbilical cords and cord sera. Here we summarize the present status of fetal exposure to endocrine disruptors in Japan and other countries.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Child Development / drug effects
  • Embryonic and Fetal Development / drug effects
  • Endocrine System / drug effects
  • Environmental Exposure / adverse effects*
  • Environmental Exposure / analysis
  • Female
  • Humans
  • Hypospadias / chemically induced
  • Infant, Newborn
  • Japan
  • Male
  • Maternal Exposure
  • Maternal-Fetal Exchange
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Umbilical Cord / chemistry
  • Xenobiotics / adverse effects*
  • Xenobiotics / analysis


  • Xenobiotics