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doi: 10.1126/science.290.5500.2271.
Cell cycle. License withheld--geminin blocks DNA replication
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- PMID: 11188727
- DOI: 10.1126/science.290.5500.2271
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Cell cycle. License withheld--geminin blocks DNA replication
Science.
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Abstract
A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase (Wohlschlegel et al.).
Comment on
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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.Science. 2000 Dec 22;290(5500):2309-12. doi: 10.1126/science.290.5500.2309. Science. 2000. PMID: 11125146
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