Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer in Japan

Gastroenterol Clin North Am. 2000 Dec;29(4):819-27. doi: 10.1016/s0889-8553(05)70149-7.


This article describes the characteristics of H. pylori infection dynamics in early gastric cancer cases in Japan and the reduced likelihood of metachronous cancer development and growth inhibition by H. pylori eradication based on healing of background gastric mucosa. In the future, these clinical studies and experimental studies in Mongolian gerbils and mice should elucidate the role of H. pylori infection in the development of gastric carcinogenesis to clinical cancer on the genetic level so that gastric cancer prevention by H. pylori eradication is established.

Publication types

  • Review

MeSH terms

  • Gastroscopy
  • Helicobacter Infections / complications
  • Helicobacter Infections / diagnosis
  • Helicobacter Infections / therapy*
  • Helicobacter pylori*
  • Humans
  • Japan
  • Metaplasia
  • Secondary Prevention
  • Severity of Illness Index
  • Stomach / pathology
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / microbiology*
  • Stomach Neoplasms / surgery