Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer

Cancer Metastasis Rev. 2000;19(1-2):93-6. doi: 10.1023/a:1026516920119.


We postulate that oncogenes and tumor suppressor genes may influence tumor angiogenesis not only directly (e.g. by upregulating vascular endothelial growth factor) but also through their impact on expression (and/or function) of tissue factor and other elements of the hemostatic system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor*
  • Hemostasis / genetics
  • Hemostasis / physiology*
  • Humans
  • Neoplasms / blood
  • Neoplasms / blood supply
  • Neoplasms / genetics*
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / physiopathology*
  • Oncogenes*