Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies. Childhood Myositis Heterogeneity Collaborative Group

Lancet. 2000 Dec 23-30;356(9248):2155-6. doi: 10.1016/s0140-6736(00)03499-1.

Abstract

We identified maternal microchimerism by fluorescence in-situ hybridisation in magnetically-separated CD4 or CD8 peripheral blood cells of eight of nine male patients with juvenile idiopathic inflammatory myopathy, compared with two of nine healthy male controls. We also found maternal microchimerism in inflammatory lesions (one skin sample and nine muscle biopsy samples) of all ten patients examined, compared with two of ten biopsy samples from patients with other muscle disorders. These results suggest that maternal cells may be involved in the pathogenesis of juvenile idiopathic inflammatory myopathy.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chimera / genetics*
  • Female
  • HLA-DQ Antigens / genetics
  • HLA-DQ alpha-Chains
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Maternal-Fetal Exchange*
  • Myositis / genetics*
  • Pregnancy
  • X Chromosome / genetics

Substances

  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQA1 antigen