Adrafinil: effects on behavior and cognition in aged canines

Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul;24(5):709-26. doi: 10.1016/s0278-5846(00)00103-2.

Abstract

1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single treatment is long-lasting, and the effectiveness persists over repeated treatments. 4. Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil causes a long-lasting increase in high frequency electroencephalographic activity recorded from cortical electrodes. 6. These results indicate that adrafinil is novel behavioral stimulant with cognitive enhancing potential. The underlying mechanisms of action are still unknown.

MeSH terms

  • Aging / psychology*
  • Animals
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / pharmacology*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiology
  • Cognition / drug effects*
  • Discrimination Learning / drug effects*
  • Dogs
  • Electroencephalography
  • Female
  • Hydroxamic Acids / administration & dosage
  • Hydroxamic Acids / pharmacology*
  • Locomotion / drug effects*
  • Male

Substances

  • Central Nervous System Stimulants
  • Hydroxamic Acids
  • adrafinil