Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation

Biosci Biotechnol Biochem. 2000 Nov;64(11):2482-5. doi: 10.1271/bbb.64.2482.


We examined whether starvation affected the amount of EF-2 protein as well as the level of its mRNA in the liver and skeletal muscle of mice, to understand the molecular mechanism for nutritional adaptation of protein-turnover. Although the amount of EF-2 was diminished by starvation in each of the tissues examined, the amount of EF-2 mRNA did not decrease in parallel with the protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Liver / metabolism*
  • Mice
  • Muscle, Skeletal / metabolism*
  • Peptide Elongation Factor 2 / genetics
  • Peptide Elongation Factor 2 / metabolism*
  • RNA, Messenger / metabolism
  • Starvation / metabolism*


  • Peptide Elongation Factor 2
  • RNA, Messenger