Membranous glomerulonephritis associated with diffuse malignant pleural mesothelioma: report of a case

Surg Today. 2000;30(12):1124-6. doi: 10.1007/s005950070014.


Membranous glomerulonephritis is associated with a variety of malignant neoplasms. However, an association between membranous glomerulonephritis and pleural mesothelioma is very rare. We report herein a case of pleural mesothelioma associated with membranous glomerulonephritis. A 52-year-old man with severe proteinuria was diagnosed to have diffuse malignant pleural mesothelioma. A left extrapleural pneumonectomy was thus performed. The proteinuria resolved postoperatively. However, 6 months postoperatively, the proteinuria recurred. A renal biopsy revealed membranous glomerulonephritis. Simultaneously, a recurrence of the mesothelioma in the left pleural cavity was confirmed. Although rare, membranous glomerulonephritis appears to be one type of paraneoplastic syndrome associated with malignant pleural mesothelioma.

Publication types

  • Case Reports

MeSH terms

  • Glomerulonephritis, Membranous / diagnosis
  • Glomerulonephritis, Membranous / etiology*
  • Glomerulonephritis, Membranous / pathology
  • Humans
  • Male
  • Mesothelioma / complications*
  • Mesothelioma / surgery
  • Middle Aged
  • Pleural Neoplasms / complications*
  • Pleural Neoplasms / surgery
  • Pneumonectomy
  • Proteinuria / etiology
  • Recurrence