Genetic factors in the genesis of Alzheimer's disease

Ann N Y Acad Sci. 2000;924:1-7. doi: 10.1111/j.1749-6632.2000.tb05552.x.


At least four different genes have been identified that are associated with inherited susceptibiltiy to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, beta APP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics*
  • Brain Chemistry / genetics*
  • Genetic Predisposition to Disease
  • Humans
  • Penetrance