The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?

Ann N Y Acad Sci. 2000;924:26-8. doi: 10.1111/j.1749-6632.2000.tb05555.x.


A central issue in Alzheimer's disease research is whether amyloid beta-protein (A beta) is a cause or effect of the pathogenic process. Several independent lines of evidence argue for causality, although human clinical trials may be required to finally settle the issue.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease* / etiology
  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / pathology
  • Amyloid beta-Peptides / metabolism*
  • Brain / metabolism
  • Brain / pathology
  • Humans


  • Amyloid beta-Peptides