p53 and p21 are major cellular determinants for DNA topoisomerase I-mediated radiation sensitization in mammalian cells

Ann N Y Acad Sci. 2000;922:298-300. doi: 10.1111/j.1749-6632.2000.tb07047.x.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • CHO Cells / drug effects
  • CHO Cells / radiation effects
  • Camptothecin / pharmacology
  • Cricetinae
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins / physiology*
  • DNA Topoisomerases, Type I / physiology*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Radiation Tolerance / drug effects
  • Radiation Tolerance / physiology*
  • Radiation-Sensitizing Agents / pharmacology
  • Topoisomerase I Inhibitors
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / radiation effects
  • Tumor Suppressor Protein p53 / physiology*

Substances

  • Antineoplastic Agents, Phytogenic
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Enzyme Inhibitors
  • Radiation-Sensitizing Agents
  • Topoisomerase I Inhibitors
  • Tumor Suppressor Protein p53
  • DNA Topoisomerases, Type I
  • Camptothecin