MICA polymorphism is associated with type 1 diabetes in the Korean population

Diabetes Care. 2001 Jan;24(1):33-8. doi: 10.2337/diacare.24.1.33.


Objective: Recent studies have demonstrated that MICA (major histocompatibility complex class I chain-related genes) on the short arm of the chromosome 6 are associated with susceptibility to various autoimmune diseases in Caucasians. The aim of our study was to investigate the role of MICA in type 1 diabetes susceptibility independent of the HLA DR-DQ polymorphism in genetically distinct Koreans.

Research design and methods: A total of 119 patients selected from Korean Seoul type 1 diabetes registry and 134 nondiabetic unrelated control subjects were typed for exon 5 polymorphism of MICA in addition to HLA DR-DQ typing. A total of 52 simplex families of type 1 diabetes were also studied.

Results: The MICA microsatellite allele consisting of six repetitions of GCT/AGC (A6) was present at a significantly lower frequency in the diabetic patient group (Pc < 0.01; Pc = P value after Bonferroni correction) than in the control population. The MICA microsatellite allele consisting of four repetitions (A4) was present at a higher frequency in diabetic patients (P < 0.05). This deviated distribution was not changed even after controlling for the HLA DRB1-DQB1 haplotype. Transmission/disequilibrium test revealed significant deviation of transmission for alleles at the A6 polymorphism within the MICA gene (P < 0.05).

Conclusions: We could assess that the MICA gene might be associated with type 1 diabetes transracially independent of the HLA gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / genetics*
  • Gene Frequency
  • Genes, MHC Class I / genetics*
  • Genes, MHC Class II / genetics
  • Genotype
  • Haplotypes
  • Humans
  • Korea
  • Linkage Disequilibrium
  • Microsatellite Repeats
  • Middle Aged
  • Polymorphism, Genetic*