American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation

J Am Coll Nutr. Nov-Dec 2000;19(6):738-44. doi: 10.1080/07315724.2000.10718073.

Abstract

Objective: We studied the effect of escalating the dose and administration time of American ginseng (AG, Panax quinquefolius L.) in nondiabetic individuals to achieve further improvements in glucose tolerance seen previously when 3 g of AG was taken 40 minutes before a 25 g glucose challenge.

Methods: Ten nondiabetic individuals (6M:4F; mean +/- STD: age = 41 +/- 13 years, BMI = 24.8 +/- 3.5 kg/m2, FBG = 4.5 +/- 0.1 mmol L(-1)) on 12 separate occasions, randomly received 0 (placebo), 3, 6 or 9 g of ground AG root at 40, 80, or 120 minutes before a 25 g oral glucose challenge. Capillary blood glucose was measured prior to ingestion of AG or placebo capsules and at 0, 15, 30, 45, 60 and 90 minutes from start of challenge.

Results: Compared with the placebo, 3, 6 and 9 g of AG reduced (p<0.05) postprandial incremental glucose at 30, 45 and 60 minutes; also, 3 and 9 g of AG did so at 90 minutes. At 60 minutes, 9 g of AG reduced incremental postprandial glucose relative to 3 g of AG (p<0.05). All AG doses reduced (p<0.05) area under the incremental glucose curve (3 g, 26.6%; 6 g, 29.3%; 9 g, 38.5%). AG taken at different times did not have an additional influence on postprandial glycemia.

Conclusions: In nondiabetic individuals, 3, 6 or 9 g of AG taken 40, 80 or 120 minutes before a glucose challenge similarly improved glucose tolerance.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Area Under Curve
  • Blood Glucose / drug effects*
  • Dose-Response Relationship, Drug
  • Female
  • Glucose Tolerance Test
  • Humans
  • Hyperglycemia / prevention & control*
  • Hypoglycemic Agents / therapeutic use*
  • Male
  • Middle Aged
  • Panax / therapeutic use*
  • Phytotherapy*
  • Plants, Medicinal*
  • Postprandial Period
  • Time Factors
  • Treatment Outcome

Substances

  • Blood Glucose
  • Hypoglycemic Agents