Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up?

J Endocrinol Invest. 2000 Dec;23(11):721-3. doi: 10.1007/BF03345059.


Estrogens locally generated from androgen precursors due to the action of aromatase play a main role in epiphyseal cartilage fusion. Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3 yr) in a boy previously operated on for a hamartoma causing precocious puberty and presenting with advanced bone maturation and nearly fused epiphyseal cartilages, slowed cartilage fusion consenting a higher final stature than expected (164.4 cm vs 158.4 cm). It is suggested that treatment with aromatase inhibitors, alone or in combination with rh-GH, may also be useful in children with constitutional short stature in order to delay epiphyseal closure and improve the final height.

Publication types

  • Case Reports

MeSH terms

  • Anastrozole
  • Aromatase Inhibitors*
  • Body Height*
  • Bone Development / drug effects
  • Child, Preschool
  • Enzyme Inhibitors / pharmacology*
  • Growth Disorders / drug therapy*
  • Growth Plate / drug effects*
  • Growth Plate / growth & development*
  • Human Growth Hormone / therapeutic use
  • Humans
  • Male
  • Nitriles / pharmacology*
  • Nitriles / therapeutic use
  • Puberty, Precocious / drug therapy
  • Triazoles / pharmacology*
  • Triazoles / therapeutic use


  • Aromatase Inhibitors
  • Enzyme Inhibitors
  • Nitriles
  • Triazoles
  • Human Growth Hormone
  • Anastrozole