Research on renal endothelin in proteinuric nephropathies dictates novel strategies to prevent progression

Curr Opin Nephrol Hypertens. 2001 Jan;10(1):1-6. doi: 10.1097/00041552-200101000-00001.


Proteinuria is one of the major risk factors for renal disease progression in patients with chronic nephropathies. Studies in disease models have helped to delineate mechanisms leading to renal structural damage as a result of persistent dysfunction of the glomerular barrier to proteins, even when the primary immune or non-immune insult to the kidney has ceased. From these preclinical studies, a role for endothelin in proteinuric chronic renal diseases has been suggested, thus providing the rationale for novel therapeutic approaches with endothelin receptor antagonists to maximize renoprotection so far achieved with blockade of the renin-angiotensin system by angiotensin-converting enzyme inhibition or angiotensin II receptor antagonism. Trials are needed to explore this potential area of clinical interest.

Publication types

  • Review

MeSH terms

  • Angiotensin II / antagonists & inhibitors
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Animals
  • Blood Pressure / drug effects
  • Disease Progression
  • Endothelin Receptor Antagonists
  • Endothelins / antagonists & inhibitors
  • Endothelins / metabolism*
  • Humans
  • Kidney / metabolism*
  • Kidney Diseases / drug therapy
  • Kidney Diseases / metabolism*
  • Kidney Diseases / urine*
  • Proteinuria / complications*


  • Angiotensin-Converting Enzyme Inhibitors
  • Endothelin Receptor Antagonists
  • Endothelins
  • Angiotensin II