Cytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cells

Curr Opin Nephrol Hypertens. 2001 Jan;10(1):55-9. doi: 10.1097/00041552-200101000-00009.


Immunostaining of renal biopsies of patients with interstitial rejection of allografts or other forms of interstitial inflammation has demonstrated the presence of activated T cells and monocytes/macrophages in the tubulointerstitial area. Cytokines that are produced by infiltrating cells are capable of activating tubular epithelial cells. In turn tubular epithelial cells can produce a wide variety of inflammatory mediators, including chemokines, which further regulate cellular influx. Interfering in this cross-talk between tubular epithelial cells and infiltrating cells might provide new options for therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis
  • Cytokines / physiology*
  • Epithelial Cells / physiology
  • Humans
  • Immunocompetence / physiology*
  • Kidney Tubules / cytology
  • Kidney Tubules / physiology*
  • Leukocytes / physiology
  • Nephritis / drug therapy
  • Nephritis / metabolism
  • Signal Transduction


  • Cytokines