Abstract
Cimetidine administered intravenously to six healthy volunteers caused a significant increase in plasma prolactin response to TRH. The meaning of these results and their relation with the physiological role of histamine H2-receptors in the control of prolactin secretion is discussed.
MeSH terms
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Blood-Brain Barrier / drug effects
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Cimetidine / administration & dosage
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Cimetidine / pharmacology*
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Guanidines / pharmacology*
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Humans
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Injections, Intravenous
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Male
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Prolactin / blood*
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Prolactin / metabolism
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Receptors, Histamine H1 / drug effects
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Receptors, Histamine H2 / drug effects
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Thyrotropin-Releasing Hormone / pharmacology*
Substances
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Guanidines
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Receptors, Histamine H1
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Receptors, Histamine H2
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Thyrotropin-Releasing Hormone
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Cimetidine
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Prolactin