An IL-13 promoter polymorphism associated with increased risk of allergic asthma

Genes Immun. 1999 Sep;1(1):61-5. doi: 10.1038/sj.gene.6363630.


IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthma / genetics*
  • Asthma / immunology*
  • Base Sequence
  • Case-Control Studies
  • DNA / genetics
  • DNA Primers / genetics
  • Genotype
  • Humans
  • Interleukin-13 / biosynthesis
  • Interleukin-13 / genetics*
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic*
  • Risk Factors


  • DNA Primers
  • Interleukin-13
  • DNA