[Transforming growth factor-beta signaling and cancer]

Hum Cell. 2000 Sep;13(3):97-101.
[Article in Japanese]

Abstract

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that inhibits the growth of most types of cells and induces fibrosis of various tissues. TGF-beta binds to two different types of serine/threonine kinase receptors, and activate Smad proteins. Perturbation of the TGF-beta signaling pathway results in tumorigenesis of various tissues. TGF-beta/Smad signaling is regulated by several regulatory proteins, including inhibitory Smads and transcriptional corepressors. Abnormalities in these negative regulators of TGF-beta signaling may also involved in tumorigenesis of certain tissues.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / pathology
  • Nuclear Proteins / metabolism
  • Nuclear Proteins / physiology
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins / physiology
  • Receptors, Transforming Growth Factor beta / metabolism
  • Receptors, Transforming Growth Factor beta / physiology
  • Signal Transduction / physiology*
  • Trans-Activators / metabolism
  • Trans-Activators / physiology
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • Transforming Growth Factor beta / metabolism
  • Transforming Growth Factor beta / physiology*

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Receptors, Transforming Growth Factor beta
  • Trans-Activators
  • Transcription Factors
  • Transforming Growth Factor beta
  • SKI protein, human