The effectiveness of combined oral lysine acetylsalicylate and metoclopramide (Migpriv) in the treatment of migraine attacks. Comparison with placebo and oral sumatriptan

Funct Neurol. 2000;15 Suppl 3:196-201.

Abstract

In two, double-blind, randomised, clinical, trials (RCTs), oral lysine acetylsalicylate (1620 mg, equivalent to 900 mg aspirin) combined with metoclopramide (10 mg) (LAS + MTC) was compared with placebo, and with oral sumatriptan (100 mg) in one of these RCTs. In both RCTs the LAS + MTC combination was superior to placebo with therapeutic gains (percentage relief after active treatment minus percentage relief after placebo) of 30% and 31% for the first treated attack. These therapeutic gains are in the same range as those found for 100 mg oral sumatriptan, and in the comparative RCT the LAS + MTC combination was quite comparable to 100 mg sumatriptan, with success rates for the first attack of 57% and 53%, respectively.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Aspirin / administration & dosage
  • Aspirin / analogs & derivatives*
  • Aspirin / therapeutic use*
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / therapeutic use*
  • Drug Combinations
  • Humans
  • Lysine / administration & dosage
  • Lysine / analogs & derivatives*
  • Lysine / therapeutic use*
  • Metoclopramide / administration & dosage
  • Metoclopramide / therapeutic use*
  • Migraine Disorders / complications
  • Migraine Disorders / drug therapy*
  • Randomized Controlled Trials as Topic
  • Serotonin Receptor Agonists / therapeutic use*
  • Sumatriptan / therapeutic use*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Dopamine Antagonists
  • Drug Combinations
  • Serotonin Receptor Agonists
  • Sumatriptan
  • Lysine
  • Metoclopramide
  • Aspirin
  • acetylsalicylic acid lysinate