The Hormone Resistin Links Obesity to Diabetes

Nature. 2001 Jan 18;409(6818):307-12. doi: 10.1038/35053000.

Abstract

Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3T3 Cells
  • Adipocytes / metabolism
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosomes, Human, Pair 19
  • Cloning, Molecular
  • DNA
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / metabolism
  • Diet
  • Female
  • Gene Expression Regulation / drug effects
  • Glucose Intolerance
  • Hormones / genetics
  • Hormones / metabolism
  • Hormones / physiology*
  • Hormones, Ectopic / genetics
  • Hormones, Ectopic / metabolism
  • Hormones, Ectopic / physiology*
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Insulin Antagonists
  • Insulin Resistance
  • Intercellular Signaling Peptides and Proteins*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Nerve Growth Factor
  • Neutralization Tests
  • Obesity*
  • Proteins*
  • Resistin
  • Rosiglitazone
  • Signal Transduction
  • Thiazoles / pharmacology
  • Thiazolidinediones*

Substances

  • Hormones
  • Hormones, Ectopic
  • Hypoglycemic Agents
  • Insulin Antagonists
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • RETN protein, human
  • RETNLB protein, human
  • Resistin
  • Retn protein, mouse
  • Retnla protein, mouse
  • Thiazoles
  • Thiazolidinediones
  • Rosiglitazone
  • DNA
  • Nerve Growth Factor
  • 2,4-thiazolidinedione

Associated data

  • GENBANK/AC008763
  • GENBANK/AF323080
  • GENBANK/AF323081