Quality of Life (QOL) of patients with Gilles de la Tourette's syndrome

Acta Psychiatr Scand. 2001 Jan;103(1):52-9. doi: 10.1034/j.1600-0447.2001.00147.x.


Objective: This is the first study to investigate the Quality of Life (QOL) of patients with Gilles de la Tourette's Syndrome (GTS).

Method: One hundred and three out-patients with GTS completed a semi-structured interview and 90 of these completed questionnaires screening for depression, anxiety and obsessive-compulsive behaviour. QOL was measured with the SF-36 and the Quality of Life Assessment Schedule (QOLAS).

Results: Patients with GTS showed significantly worse QOL than a general population sample. They had better QOL than patients with intractable epilepsy as measured by the QOLAS, although the SF-36 showed significant differences on the subscales Role Limitation due to physical problems and Social Functioning only. Factors influencing QOL domains were employment status, tic severity, obsessive-compulsive behaviour, anxiety and depression.

Conclusion: QOL is impaired in patients with GTS. Measurement of QOL could be used alongside conventional measurements to assess benefit of treatment. We recommend the QOLAS and SF-36 be used.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anxiety / complications
  • Anxiety / psychology
  • Depression / complications
  • Depression / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / complications
  • Obsessive-Compulsive Disorder / psychology
  • Predictive Value of Tests
  • Psychiatric Status Rating Scales
  • Quality of Life*
  • Sampling Studies
  • Severity of Illness Index
  • Socioeconomic Factors
  • Tourette Syndrome / complications*
  • Tourette Syndrome / psychology*
  • United Kingdom