Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice

Jpn J Pharmacol. 2000 Dec;84(4):462-6. doi: 10.1254/jjp.84.462.


To assess the itch-associated response of primary afferents innervating the murine skin in vivo, dose-response curves and time-courses for itch-scratching and cutaneous nerve firing responses to intradermal injections of pruritogens (histamine and serotonin) were compared in ICR and ddY mice. Serotonin increased the itch-scratch response and cutaneous nerve firing in either ICR or ddY mice. Histamine increased these two responses in ICR, but not ddY, mice. The dose-response curves and time-courses for serotonin- and histamine-induced nerve firing were similar to those for the itch-scratch response. The results suggest that cutaneous nerve firing evoked by peripherally given pruritogens includes the itch-associated response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects*
  • Action Potentials / physiology
  • Animals
  • Dose-Response Relationship, Drug
  • Free Radical Scavengers / pharmacology*
  • Histamine / pharmacology*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Models, Animal
  • Neurons, Afferent / drug effects*
  • Neurons, Afferent / physiology
  • Pruritus / chemically induced
  • Pruritus / physiopathology*
  • Serotonin / pharmacology*
  • Skin / drug effects*
  • Skin / innervation
  • Species Specificity


  • Free Radical Scavengers
  • Serotonin
  • Histamine