The effects of collagen hydrolysat on symptoms of chronic fibromyalgia and temporomandibular joint pain

Cranio. 2000 Apr;18(2):135-41. doi: 10.1080/08869634.2000.11746125.


Twenty (20) people who had medically diagnosed fibromyalgia for two to 15+ years participated in and completed a 90-day evaluation to determine effects of collagen hydrolysat on symptoms of chronic fibromyalgia, with twelve reporting temporomandibular joint pain. Collagen hydrolysat is a food supplement that is available without prescription, with no known side effects. Participants were evaluated initially and then at 30-, 60-, and 90-day periods. Final results were obtained and comparisons made. The average pain complaint levels decreased significantly in an overall group average, and dramatically with some individuals. It was concluded that patients with fibromyalgia and concurrent temporomandibular joint problems may gain symptomatic improvement in their chronic symptoms by taking collagen hydrolysat.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Chronic Disease
  • Collagen / therapeutic use*
  • Dietary Supplements*
  • Facial Pain / drug therapy*
  • Female
  • Fibromyalgia / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Protein Hydrolysates / therapeutic use*
  • Temporomandibular Joint Dysfunction Syndrome / drug therapy*


  • Protein Hydrolysates
  • Collagen