Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome

F Rouleau; P Asfar; S Boulet; L Dube; J M Dupuis; P Alquier; J Victor

doi:10.1046/j.1540-8167.2001.00061.x

Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome

J Cardiovasc Electrophysiol. 2001 Jan;12(1):61-5. doi: 10.1046/j.1540-8167.2001.00061.x.

Authors

F Rouleau¹, P Asfar, S Boulet, L Dube, J M Dupuis, P Alquier, J Victor

Affiliation

¹ Département de Cardiologie, Centre Hospitalier Universitaire d'Angers, France.

PMID: 11204086
DOI: 10.1046/j.1540-8167.2001.00061.x

Abstract

Psychotropic Drugs and ST Segment Elevation. Transient ST segment elevation in right precordial leads with use of psychotropic drugs is reported in two cases of overdose and one case of therapeutic administration. Flecainide did not reproduce ST segment elevation. The relationship of these abnormalities to the Brugada syndrome and the electrophysiologic hypothesis are discussed.

Publication types

Case Reports

MeSH terms

Adult
Amitriptyline / adverse effects
Antidepressive Agents, Second-Generation / adverse effects
Antidepressive Agents, Tricyclic / adverse effects
Antipsychotic Agents / adverse effects
Bundle-Branch Block / complications
Bundle-Branch Block / physiopathology
Death, Sudden, Cardiac / etiology
Electrocardiography*
Female
Fluoxetine / adverse effects
Heart / drug effects*
Heart / physiopathology*
Humans
Male
Middle Aged
Phenothiazines / adverse effects
Psychotropic Drugs / adverse effects*
Syndrome
Time Factors

Substances

Antidepressive Agents, Second-Generation
Antidepressive Agents, Tricyclic
Antipsychotic Agents
Phenothiazines
Psychotropic Drugs
Fluoxetine
Amitriptyline
cyamemazine