Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man

Eur J Gastroenterol Hepatol. 2001 Jan;13(1):25-9. doi: 10.1097/00042737-200101000-00005.


Objective: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylori infection.

Design and methods: Fifty-three volunteers infected with H. pylori as determined by positive 13C-urea breath test and positive serology were randomized to receive either LC-1 or a placebo 180 ml twice a day for 3 weeks. All subjects also received clarithromycin 500 mg bid during the last two weeks of acidified milk therapy. Oesophagogastroduodenoscopy and biopsies were performed at inclusion and repeated 4-8 weeks after the end of the treatment. H. pylori infection was confirmed by urease test and histology. H. pylori density and inflammation were scored using a modified Sydney classification.

Results: LC-1 ingestion induced a decrease in H. pylori density in the antrum (P= 0.02) and the corpus (P= 0.04). LC-1 also reduced inflammation and gastritis activity in the antrum (P= 0.02 and P= 0.01, respectively) and of activity in the corpus (P= 0.02). Clarithromycin eradicated H. pylori in 26% of the subjects; LC-1 did not improve the antibiotic effect.

Conclusion: These results suggest that H. pylori infection and gastritis can be down-regulated by LC-1.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Breath Tests
  • Clarithromycin / therapeutic use
  • Double-Blind Method
  • Female
  • Gastritis / microbiology*
  • Gastritis / therapy*
  • Helicobacter Infections / therapy*
  • Helicobacter pylori*
  • Humans
  • Lactobacillus acidophilus*
  • Male
  • Milk / microbiology*
  • Pyloric Antrum / microbiology


  • Anti-Bacterial Agents
  • Clarithromycin