The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma

Anticancer Res. Nov-Dec 2000;20(6B):4351-3.

Abstract

Background: The tumors of the gastrointestinal system have been associated with various immune disorders. The goal of this study was to correlate the presence of the anti-dsDNA autoantibodies in the serum of patients with colorectal adenocarcinoma suffering from the prognosis of their disease.

Patients and methods: We investigated 55 patients with colorectal adenocarcinoma, 26 patients with benign surgical disease and 40 healthy volunteers for the presence of anti-dsDNA autoantibodies pre-operatively and one month post-operatively, with an ELISA technique.

Results: The difference of prevalence of anti-dsDNA antibodies between the group of cancer patients and the two control groups was statistically significant (p < 0.001). After a 3-year follow-up, the difference of incidence of the recurrences between the positive and the negative group for anti-dsDNA autoantibodies of the CA patients was statistically significant (P < 0.01).

Conclusion: The presence of anti-dsDNA autoantibodies in patients with colorectal cancer indicated a better outcome of the course of the disease.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Neoplasm / analysis*
  • Autoantibodies / analysis*
  • Case-Control Studies
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / immunology*
  • Colonic Neoplasms / surgery
  • DNA, Neoplasm / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / immunology
  • Postoperative Period
  • Prognosis
  • Rectal Neoplasms / genetics
  • Rectal Neoplasms / immunology*
  • Rectal Neoplasms / surgery

Substances

  • Antibodies, Neoplasm
  • Autoantibodies
  • DNA, Neoplasm