An elevated serum level of transforming growth factor-beta 1 (TGF-beta 1) significantly correlated with lymph node metastasis and poor prognosis in patients with gastric carcinoma

Anticancer Res. Nov-Dec 2000;20(6B):4489-93.

Abstract

Background: Overexpression of transforming growth factor beta s (TGF-beta s), multifunctional polypeptides, have been reported in the tissue of various types of carcinomas, including gastric carcinoma. To our knowledge, serum levels of TGF-beta 1 have not previously been examined in patients with gastric carcinoma as a possible indicator of prognosis.

Methods: Preoperative serum levels of TGF-beta 1 were measured in 111 patients with gastric carcinoma by an enzyme-linked immunosorbent assay.

Results: An elevated level of TGF-beta 1 was significantly correlated with lymph node metastasis and poor prognosis. Moreover, the preoperative serum levels of TGF-beta 1 in patients with peritoneal recurrence were significantly higher than those in patients both with lymph node recurrence and without recurrence.

Conclusion: The serum level of TGF-beta 1 might be useful for predicting recurrence patterns and prognosis in patients with gastric carcinoma.

MeSH terms

  • Analysis of Variance
  • Carcinoma / blood*
  • Carcinoma / secondary
  • Carcinoma / surgery
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Proteins / blood*
  • Neoplasm Recurrence, Local
  • Prognosis
  • Proportional Hazards Models
  • Stomach Neoplasms / blood*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery
  • Survival Analysis
  • Transforming Growth Factor beta / blood*
  • Transforming Growth Factor beta1

Substances

  • Neoplasm Proteins
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1