Prognostic Value of E-cadherin, Beta-Catenin, P120ctn in Patients With Transitional Cell Bladder Cancer

Anticancer Res. Nov-Dec 2000;20(6B):4571-8.

Abstract

Background: Loss of E-cadherin-catenin mediated adhesion is known to play a major role in tumour progression in many human carcinomas.

Materials and methods: By means of immunohistochemistry, we have investigated the expression of E-cadherin, beta-catenin and p120ctn in 102 transitional cell bladder carcinomas (TCCs) and statistically analysed these expressions with known clinicopathological parameters and patient survival.

Results: Abnormal expression of E-cadherin, beta-catenin and p120ctn was associated with high grade and high stage of TCCs (p < 0.001). Abnormal beta-catenin expression demonstrated a statistically significant correlation with poor patient survival (p = 0.03) while abnormal E-cadherin expression was associated with poor survival in patients with muscle invasive TCCs (p = 0.025). However, in multivariate statistical analysis a suggestive association with poor survival was observed only for E-cadherin (p = 0.06). Simultaneous abnormal expression of all the molecules demonstrated an association of suggestive significance with poor patient survival (p = 0.07).

Conclusion: E-cadherin expression may be a useful prognostic marker in patients with invasive TCCs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Biomarkers, Tumor / metabolism
  • Cadherins / metabolism*
  • Carcinoma, Transitional Cell / metabolism*
  • Carcinoma, Transitional Cell / mortality
  • Carcinoma, Transitional Cell / pathology
  • Catenins
  • Cell Adhesion Molecules / metabolism*
  • Confidence Intervals
  • Cytoskeletal Proteins / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Proteins / metabolism*
  • Neoplasm Staging
  • Phosphoproteins / metabolism*
  • Prognosis
  • Regression Analysis
  • Trans-Activators*
  • Urinary Bladder Neoplasms / metabolism*
  • Urinary Bladder Neoplasms / mortality
  • Urinary Bladder Neoplasms / pathology
  • beta Catenin

Substances

  • Biomarkers, Tumor
  • CTNNB1 protein, human
  • Cadherins
  • Catenins
  • Cell Adhesion Molecules
  • Cytoskeletal Proteins
  • Neoplasm Proteins
  • Phosphoproteins
  • Trans-Activators
  • beta Catenin
  • delta catenin