The natural history of multiple sclerosis

Neurol Sci. 2000;21(4 Suppl 2):S815-7. doi: 10.1007/s100720070018.


The natural history of chronic diseases is generally poorly understood. Multiple sclerosis is one of the best-studied diseases and we outline here some of the information obtained from 25,000 patient-years of observation. This population-based cohort received almost no treatment and certainly none known to alter the long-term natural course of the illness. There is a possibility that such data will prove useful in new generation clinical trials which are observational in nature.

Publication types

  • Review

MeSH terms

  • Cohort Studies
  • Disability Evaluation
  • Follow-Up Studies
  • Humans
  • London / epidemiology
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / physiopathology*
  • Recurrence