Prognosis of multiple sclerosis: environmental factors

Neurol Sci. 2000;21(4 Suppl 2):S839-42. doi: 10.1007/s100720070022.


Epidemiological data have suggested a role for environmental factors in multiple sclerosis etiology. Infectious diseases, exposure to toxins, immunizations, nutritional and hormonal variables, and trauma are the most studied and biologically plausible risk factors for MS. Their putative role in determining or simply triggering MS development in genetically prone subjects suggests a possible involvement of the same factors in modulating the subsequent behavior of the disease and its prognosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Environmental Exposure / adverse effects*
  • Humans
  • Life Style / ethnology
  • Multiple Sclerosis / etiology*
  • Multiple Sclerosis / physiopathology*
  • Prognosis
  • Risk Factors
  • Seasons