Is multiple sclerosis severity a genetically influenced trait?

Neurol Sci. 2000;21(4 Suppl 2):S843-7. doi: 10.1007/s100720070023.


Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system of unknown pathogenesis, is a complex disease with a multifactorial etiology determined by both genetic and environmental factors. The pathological entity MS has a wide phenotype, and also the severity of the disease is widely variable. Clinical heterogeneity of the disease might arise from different genotype-phenotype interactions. Results of recent studies and theories about the modifying role of different genes in the course and the severity of MS are here discussed.

Publication types

  • Review

MeSH terms

  • Apolipoproteins E / genetics
  • Chromosomes, Human, Pair 17 / genetics
  • Disease Progression
  • Genetic Linkage / genetics
  • Humans
  • Interleukins / genetics
  • Multigene Family / genetics
  • Multiple Sclerosis / genetics*
  • Polymorphism, Genetic / genetics
  • Receptors, Estrogen / genetics


  • Apolipoproteins E
  • Interleukins
  • Receptors, Estrogen