Marked improvement of severe cardiac dysfunction after one course of intravenous immunoglobulin in a patient with systemic lupus erythematosus

Clin Rheumatol. 1999;18(3):238-40. doi: 10.1007/s100670050091.


Intravenous immunoglobulin (IVIg) is currently used with much enthusiasm for the treatment of many autoimmune diseases, including systemic lupus erythematosus (SLE). Among its various indications, IVIg has also been found to be beneficial in myocarditis, whether or not it is associated with an autoimmune disease (e.g. Kawasaki's disease). We report a 59-year-old SLE patient who, while being treated with steroids, developed severe cardiac dysfunction with a left ventricular ejection fraction of 20%. Coronary angiography demonstrating normal coronary arteries supported the diagnosis of myocarditis. High-dose IVIg treatment was started, followed by improved cardiac function a few days later and normalisation of the ejection fraction (50%) 1 month later. This is the second report of a beneficial effect of IVIg in myocarditis secondary to SLE.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / therapy*
  • Middle Aged
  • Myocarditis / etiology
  • Myocarditis / therapy*
  • Prednisone / therapeutic use
  • Treatment Outcome
  • Ventricular Dysfunction, Left / therapy*


  • Immunoglobulins, Intravenous
  • Prednisone