Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates

Bioorg Med Chem Lett. 2001 Jan 22;11(2):157-60. doi: 10.1016/s0960-894x(00)00612-0.


A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism
  • Dinucleoside Phosphates / chemical synthesis
  • Dinucleoside Phosphates / metabolism*
  • Humans
  • Protein Binding
  • Purinergic P2 Receptor Agonists*
  • Receptors, Purinergic P2 / metabolism
  • Spectrometry, Fluorescence
  • Structure-Activity Relationship
  • Transduction, Genetic
  • Tumor Cells, Cultured
  • Uracil Nucleotides / chemical synthesis
  • Uracil Nucleotides / metabolism*


  • Dinucleoside Phosphates
  • Purinergic P2 Receptor Agonists
  • Receptors, Purinergic P2
  • Uracil Nucleotides
  • Calcium