Background: Various alloplastic injectable implants have been developed for soft tissue augmentation without surgery, but different local or systemic adverse reactions have limited their use for cosmetic purposes.
Objective: To examine the problems associated with silicone injection.
Methods: Case report and literature review.
Results: We describe an adverse granulomatous reaction after the injection of liquid silicone for lip augmentation, causing facial disfigurement. Although the initial response to steroids was poor, after 3 years of follow-up the nodules have almost disappeared spontaneously.
Conclusion: We advise that silicone injection be performed solely by trained physicians using medical-grade silicone or consider other injectable materials.