Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles

Traffic. 2000 Dec;1(12):927-34.


Centrosomes and other microtubule organizing centers are the largest non-membranous organelles in most cells. This morphologically diverse class of organelles shares a common ability to nucleate and organize microtubules in interphase and participates in the formation of mitotic spindles during cell division. This review summarizes recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens / metabolism
  • Autoantigens / metabolism
  • Biological Transport
  • CHO Cells
  • Cell Cycle Proteins*
  • Centrosome / metabolism*
  • Cricetinae
  • Dyneins / metabolism*
  • Microtubules / metabolism
  • Models, Molecular
  • Molecular Motor Proteins / metabolism*
  • Nuclear Proteins / metabolism
  • Spindle Apparatus / metabolism*


  • Antigens
  • Autoantigens
  • Cell Cycle Proteins
  • Molecular Motor Proteins
  • Nuclear Proteins
  • pericentrin
  • Dyneins