Intracellular surveillance: controlling the assembly of MHC class I-peptide complexes

Traffic. 2000 Apr;1(4):301-5. doi: 10.1034/j.1600-0854.2000.010402.x.

Abstract

MHC class I molecules bind with high affinity to peptides in the endoplasmic reticulum and display them on the cell surface. Here they are screened by CD8-positive T-lymphocytes for the presence of foreign, pathogen-derived peptides within the mass of self-peptides expressed. MHC class I assembly is a complicated process involving a number of accessory molecules, including specialized components as well as common chaperones. Our understanding of the mechanisms involved, while quite advanced, is far from complete.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / metabolism
  • Endoplasmic Reticulum / metabolism
  • Histocompatibility Antigens Class I / chemistry*
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Models, Biological
  • Molecular Chaperones / metabolism
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Transport

Substances

  • Histocompatibility Antigens Class I
  • Molecular Chaperones
  • Peptides