Estimation of antithyroid antibodies occurrence in children with coeliac disease

Med Sci Monit. 2000 Jul-Aug;6(4):719-21.


Introduction: The coexistence of coeliac disease (CD) and the diseases of autoimmune origin is often discussed in literature. In this study the evaluation of antithyroid antibodies (antimicrosomal-TMA, anti-thyreoglobulin-ATG, thyroid peroxidase antibodies anti-TPO) occurrence against clinical and laboratory determinants of thyroid function is demonstrated in children with coeliac disease.

Material and methods: The study was conducted on 34 IgA-EmA positive children; control group consisted of 28 children with negative screening tests for coeliac disease.

Results: In both groups, the level of antithyroid antibodies (TMA, ATG, anti-TPO) and determinants of thyroid gland function (TSH, fT3, fT4) were evaluated; USG examination of thyroid gland was also performed. Elevated titres of antithyroid antibodies observed in children with coeliac disease (41.1%) in comparison to control group (3.56%) indicate the need for performing the screening tests for antithyroid antibodies in children with CD.

MeSH terms

  • Adolescent
  • Autoantibodies / blood*
  • Case-Control Studies
  • Celiac Disease / etiology
  • Celiac Disease / immunology*
  • Celiac Disease / physiopathology
  • Child
  • Child, Preschool
  • Humans
  • Iodide Peroxidase / immunology
  • Microsomes / immunology
  • Thyroglobulin / immunology
  • Thyroid Gland / immunology*
  • Thyroid Gland / physiopathology


  • Autoantibodies
  • Thyroglobulin
  • Iodide Peroxidase